Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema.
Identifieur interne : 003561 ( Main/Exploration ); précédent : 003560; suivant : 003562Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema.
Auteurs : C E Markhus [Norvège] ; T V Karlsen ; Marek Wagner ; M. Wagner ; S. Svendsen ; O. Tenstad ; Kari Alitalo [Finlande] ; H. WiigSource :
- Arteriosclerosis, thrombosis, and vascular biology [ 1524-4636 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Collagène (métabolisme), Eczéma de contact allergique (anatomopathologie), Eczéma de contact allergique (génétique), Eczéma de contact allergique (immunologie), Eczéma de contact allergique (métabolisme), Eczéma de contact allergique (physiopathologie), Facteurs temps, Femelle, Fibrose, Génotype, Interleukine-12 (métabolisme), Interleukine-2 (métabolisme), Interleukine-6 (métabolisme), Liquide extracellulaire (métabolisme), Lymphoedème (anatomopathologie), Lymphoedème (génétique), Lymphoedème (immunologie), Lymphoedème (métabolisme), Lymphoedème (physiopathologie), Macrophages (immunologie), Modèles animaux de maladie humaine, Mâle, Médiateurs de l'inflammation (métabolisme), Peau (anatomopathologie), Peau (immunologie), Peau (métabolisme), Peau (physiopathologie), Perméabilité, Phénotype, Pression osmotique, Protéines (métabolisme), Récepteur-3 au facteur croissance endothéliale vasculaire (génétique), Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme), Souris, Souris de lignée C57BL, Souris transgéniques, Sérumalbumine (métabolisme), Troubles de l'équilibre hydroélectrolytique (anatomopathologie), Troubles de l'équilibre hydroélectrolytique (immunologie), Troubles de l'équilibre hydroélectrolytique (métabolisme), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (immunologie), Vaisseaux lymphatiques (métabolisme), Vaisseaux lymphatiques (physiopathologie).
- MESH :
- anatomopathologie : Eczéma de contact allergique, Lymphoedème, Peau, Troubles de l'équilibre hydroélectrolytique, Vaisseaux lymphatiques.
- génétique : Eczéma de contact allergique, Lymphoedème, Récepteur-3 au facteur croissance endothéliale vasculaire.
- immunologie : Eczéma de contact allergique, Lymphoedème, Macrophages, Peau, Troubles de l'équilibre hydroélectrolytique, Vaisseaux lymphatiques.
- métabolisme : Collagène, Eczéma de contact allergique, Interleukine-12, Interleukine-2, Interleukine-6, Liquide extracellulaire, Lymphoedème, Médiateurs de l'inflammation, Peau, Protéines, Récepteur-3 au facteur croissance endothéliale vasculaire, Sérumalbumine, Troubles de l'équilibre hydroélectrolytique, Vaisseaux lymphatiques.
- physiopathologie : Eczéma de contact allergique, Lymphoedème, Peau, Vaisseaux lymphatiques.
- Animaux, Facteurs temps, Femelle, Fibrose, Génotype, Modèles animaux de maladie humaine, Mâle, Perméabilité, Phénotype, Pression osmotique, Souris, Souris de lignée C57BL, Souris transgéniques.
English descriptors
- KwdEn :
- Animals, Collagen (metabolism), Dermatitis, Allergic Contact (genetics), Dermatitis, Allergic Contact (immunology), Dermatitis, Allergic Contact (metabolism), Dermatitis, Allergic Contact (pathology), Dermatitis, Allergic Contact (physiopathology), Disease Models, Animal, Extracellular Fluid (metabolism), Female, Fibrosis, Genotype, Inflammation Mediators (metabolism), Interleukin-12 (metabolism), Interleukin-2 (metabolism), Interleukin-6 (metabolism), Lymphatic Vessels (immunology), Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Lymphatic Vessels (physiopathology), Lymphedema (genetics), Lymphedema (immunology), Lymphedema (metabolism), Lymphedema (pathology), Lymphedema (physiopathology), Macrophages (immunology), Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Osmotic Pressure, Permeability, Phenotype, Proteins (metabolism), Serum Albumin (metabolism), Skin (immunology), Skin (metabolism), Skin (pathology), Skin (physiopathology), Time Factors, Vascular Endothelial Growth Factor Receptor-3 (genetics), Vascular Endothelial Growth Factor Receptor-3 (metabolism), Water-Electrolyte Imbalance (immunology), Water-Electrolyte Imbalance (metabolism), Water-Electrolyte Imbalance (pathology).
- MESH :
- chemical , genetics : Vascular Endothelial Growth Factor Receptor-3.
- chemical , metabolism : Collagen, Inflammation Mediators, Interleukin-12, Interleukin-2, Interleukin-6, Proteins, Serum Albumin, Vascular Endothelial Growth Factor Receptor-3.
- genetics : Dermatitis, Allergic Contact, Lymphedema.
- immunology : Dermatitis, Allergic Contact, Lymphatic Vessels, Lymphedema, Macrophages, Skin, Water-Electrolyte Imbalance.
- metabolism : Dermatitis, Allergic Contact, Extracellular Fluid, Lymphatic Vessels, Lymphedema, Skin, Water-Electrolyte Imbalance.
- pathology : Dermatitis, Allergic Contact, Lymphatic Vessels, Lymphedema, Skin, Water-Electrolyte Imbalance.
- physiopathology : Dermatitis, Allergic Contact, Lymphatic Vessels, Lymphedema, Skin.
- Animals, Disease Models, Animal, Female, Fibrosis, Genotype, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Osmotic Pressure, Permeability, Phenotype, Time Factors.
Abstract
The pathophysiology of lymphedema is incompletely understood. We asked how transcapillary fluid balance parameters and lymph flow are affected in a transgenic mouse model of primary lymphedema, which due to an inhibition of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling lacks dermal lymphatics, and whether protein accumulation in the interstitium occurring in lymphedema results in inflammation.
DOI: 10.1161/ATVBAHA.112.300384
PubMed: 23288156
Affiliations:
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Le document en format XML
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Wagner</name></author><author><name sortKey="Svendsen, S" sort="Svendsen, S" uniqKey="Svendsen " first=" S" last="Svendsen"> S. Svendsen</name></author><author><name sortKey="Tenstad, O" sort="Tenstad, O" uniqKey="Tenstad O" first="O" last="Tenstad">O. Tenstad</name></author><author><name sortKey="Alitalo, K" sort="Alitalo, K" uniqKey="Alitalo K" first="K" last="Alitalo">Kari Alitalo</name><affiliation><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Wiig, H" sort="Wiig, H" uniqKey="Wiig H" first="H" last="Wiig">H. Wiig</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23288156</idno><idno type="pmid">23288156</idno><idno type="doi">10.1161/ATVBAHA.112.300384</idno><idno type="wicri:Area/PubMed/Corpus">001D66</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D66</idno><idno type="wicri:Area/PubMed/Curation">001D66</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001D66</idno><idno type="wicri:Area/PubMed/Checkpoint">001D66</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001D66</idno><idno type="wicri:Area/Ncbi/Merge">005487</idno><idno type="wicri:Area/Ncbi/Curation">005487</idno><idno type="wicri:Area/Ncbi/Checkpoint">005487</idno><idno type="wicri:Area/Main/Merge">003567</idno><idno type="wicri:Area/Main/Curation">003561</idno><idno type="wicri:Area/Main/Exploration">003561</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema.</title><author><name sortKey="Markhus, C E" sort="Markhus, C E" uniqKey="Markhus C" first="C E" last="Markhus">C E Markhus</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedicine, University of Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Biomedicine, University of Bergen</wicri:regionArea><wicri:noRegion>University of Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Karlsen, T V" sort="Karlsen, T V" uniqKey="Karlsen T" first="T V" last="Karlsen">T V Karlsen</name></author><author><name sortKey="Wagner, Marek" sort="Wagner, Marek" uniqKey="Wagner M" first="Marek" last="Wagner">Marek Wagner</name></author><author><name sortKey="Wagner, M" sort="Wagner, M" uniqKey="Wagner M" first="M" last="Wagner">M. Wagner</name></author><author><name sortKey="Svendsen, S" sort="Svendsen, S" uniqKey="Svendsen " first=" S" last="Svendsen"> S. Svendsen</name></author><author><name sortKey="Tenstad, O" sort="Tenstad, O" uniqKey="Tenstad O" first="O" last="Tenstad">O. Tenstad</name></author><author><name sortKey="Alitalo, K" sort="Alitalo, K" uniqKey="Alitalo K" first="K" last="Alitalo">Kari Alitalo</name><affiliation><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Wiig, H" sort="Wiig, H" uniqKey="Wiig H" first="H" last="Wiig">H. Wiig</name></author></analytic><series><title level="j">Arteriosclerosis, thrombosis, and vascular biology</title><idno type="eISSN">1524-4636</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Collagen (metabolism)</term><term>Dermatitis, Allergic Contact (genetics)</term><term>Dermatitis, Allergic Contact (immunology)</term><term>Dermatitis, Allergic Contact (metabolism)</term><term>Dermatitis, Allergic Contact (pathology)</term><term>Dermatitis, Allergic Contact (physiopathology)</term><term>Disease Models, Animal</term><term>Extracellular Fluid (metabolism)</term><term>Female</term><term>Fibrosis</term><term>Genotype</term><term>Inflammation Mediators (metabolism)</term><term>Interleukin-12 (metabolism)</term><term>Interleukin-2 (metabolism)</term><term>Interleukin-6 (metabolism)</term><term>Lymphatic Vessels (immunology)</term><term>Lymphatic Vessels (metabolism)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphatic Vessels (physiopathology)</term><term>Lymphedema (genetics)</term><term>Lymphedema (immunology)</term><term>Lymphedema (metabolism)</term><term>Lymphedema (pathology)</term><term>Lymphedema (physiopathology)</term><term>Macrophages (immunology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Transgenic</term><term>Osmotic Pressure</term><term>Permeability</term><term>Phenotype</term><term>Proteins (metabolism)</term><term>Serum Albumin (metabolism)</term><term>Skin (immunology)</term><term>Skin (metabolism)</term><term>Skin (pathology)</term><term>Skin (physiopathology)</term><term>Time Factors</term><term>Vascular Endothelial Growth Factor Receptor-3 (genetics)</term><term>Vascular Endothelial Growth Factor Receptor-3 (metabolism)</term><term>Water-Electrolyte Imbalance (immunology)</term><term>Water-Electrolyte Imbalance (metabolism)</term><term>Water-Electrolyte Imbalance (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Collagène (métabolisme)</term><term>Eczéma de contact allergique (anatomopathologie)</term><term>Eczéma de contact allergique (génétique)</term><term>Eczéma de contact allergique (immunologie)</term><term>Eczéma de contact allergique (métabolisme)</term><term>Eczéma de contact allergique (physiopathologie)</term><term>Facteurs temps</term><term>Femelle</term><term>Fibrose</term><term>Génotype</term><term>Interleukine-12 (métabolisme)</term><term>Interleukine-2 (métabolisme)</term><term>Interleukine-6 (métabolisme)</term><term>Liquide extracellulaire (métabolisme)</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (génétique)</term><term>Lymphoedème (immunologie)</term><term>Lymphoedème (métabolisme)</term><term>Lymphoedème (physiopathologie)</term><term>Macrophages (immunologie)</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Médiateurs de l'inflammation (métabolisme)</term><term>Peau (anatomopathologie)</term><term>Peau (immunologie)</term><term>Peau (métabolisme)</term><term>Peau (physiopathologie)</term><term>Perméabilité</term><term>Phénotype</term><term>Pression osmotique</term><term>Protéines (métabolisme)</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire (génétique)</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme)</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris transgéniques</term><term>Sérumalbumine (métabolisme)</term><term>Troubles de l'équilibre hydroélectrolytique (anatomopathologie)</term><term>Troubles de l'équilibre hydroélectrolytique (immunologie)</term><term>Troubles de l'équilibre hydroélectrolytique (métabolisme)</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (immunologie)</term><term>Vaisseaux lymphatiques (métabolisme)</term><term>Vaisseaux lymphatiques (physiopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Collagen</term><term>Inflammation Mediators</term><term>Interleukin-12</term><term>Interleukin-2</term><term>Interleukin-6</term><term>Proteins</term><term>Serum Albumin</term><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Eczéma de contact allergique</term><term>Lymphoedème</term><term>Peau</term><term>Troubles de l'équilibre hydroélectrolytique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dermatitis, Allergic Contact</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Eczéma de contact allergique</term><term>Lymphoedème</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Eczéma de contact allergique</term><term>Lymphoedème</term><term>Macrophages</term><term>Peau</term><term>Troubles de l'équilibre hydroélectrolytique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dermatitis, Allergic Contact</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Macrophages</term><term>Skin</term><term>Water-Electrolyte Imbalance</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dermatitis, Allergic Contact</term><term>Extracellular Fluid</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Skin</term><term>Water-Electrolyte Imbalance</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Collagène</term><term>Eczéma de contact allergique</term><term>Interleukine-12</term><term>Interleukine-2</term><term>Interleukine-6</term><term>Liquide extracellulaire</term><term>Lymphoedème</term><term>Médiateurs de l'inflammation</term><term>Peau</term><term>Protéines</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term><term>Sérumalbumine</term><term>Troubles de l'équilibre hydroélectrolytique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dermatitis, Allergic Contact</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Skin</term><term>Water-Electrolyte Imbalance</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Eczéma de contact allergique</term><term>Lymphoedème</term><term>Peau</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dermatitis, Allergic Contact</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Fibrosis</term><term>Genotype</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Transgenic</term><term>Osmotic Pressure</term><term>Permeability</term><term>Phenotype</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs temps</term><term>Femelle</term><term>Fibrose</term><term>Génotype</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Perméabilité</term><term>Phénotype</term><term>Pression osmotique</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris transgéniques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathophysiology of lymphedema is incompletely understood. We asked how transcapillary fluid balance parameters and lymph flow are affected in a transgenic mouse model of primary lymphedema, which due to an inhibition of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling lacks dermal lymphatics, and whether protein accumulation in the interstitium occurring in lymphedema results in inflammation.</div></front></TEI><affiliations><list><country><li>Finlande</li><li>Norvège</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><noCountry><name sortKey="Karlsen, T V" sort="Karlsen, T V" uniqKey="Karlsen T" first="T V" last="Karlsen">T V Karlsen</name><name sortKey="Svendsen, S" sort="Svendsen, S" uniqKey="Svendsen " first=" S" last="Svendsen"> S. Svendsen</name><name sortKey="Tenstad, O" sort="Tenstad, O" uniqKey="Tenstad O" first="O" last="Tenstad">O. Tenstad</name><name sortKey="Wagner, M" sort="Wagner, M" uniqKey="Wagner M" first="M" last="Wagner">M. Wagner</name><name sortKey="Wagner, Marek" sort="Wagner, Marek" uniqKey="Wagner M" first="Marek" last="Wagner">Marek Wagner</name><name sortKey="Wiig, H" sort="Wiig, H" uniqKey="Wiig H" first="H" last="Wiig">H. Wiig</name></noCountry><country name="Norvège"><noRegion><name sortKey="Markhus, C E" sort="Markhus, C E" uniqKey="Markhus C" first="C E" last="Markhus">C E Markhus</name></noRegion></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Alitalo, K" sort="Alitalo, K" uniqKey="Alitalo K" first="K" last="Alitalo">Kari Alitalo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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